Association Clinique et Thérapeutique Infantile du Val de Marne


ACTIV is an approved organisation under the research tax credit (section 244, B II of the CGI).


In brief, the research includes the following:

  • Nasopharyngal carriage study
  • Evolution of pneumococcal serotypes responsible for ear infections before and after the introduction of the pneumococcal conjugate vaccine
  • National observatory of bacterial meningitis
  • Observatory of invasive pneumococcal disease
  • Observatory of pneumonia
  • Serious pneumococcal infection genetic factors
  • Hospitalized chickenpox in Ile de France
  • E. coli extended-spectrum beta-lactamases
  • "Ambulatory" pertussis in pediatrics
  • Failure of otitis
  • Child behaviour during illness
  • Rapid diagnositic tests (RDTs) for group A streptococcal disease (GAS)
  • C-reactive protein micromethods
  • RDTs for flu
  • Etc…

In détail :

ACTIV coordinates multiple networks of national supervision including the following:

  • Nasopharyngeal carriage of Streptococcus pneumoniae
  • National surveillance of bacterial meningitis
  • Surveillance of pneumonia
  • Surveillance of varicella
  • Surveillance of pneumococcal invasive infections

Besides this surveillance network, other kinds of studies include the following:

  • Comparison of 2 antibiotics or durations of treatment
  • Specific studies to evaluate the impact of antibiotics on the composition of nasopharyngeal flora bacteria and their resistance to antibiotics. To account for the importance of bacterial resistance in community infections, we began studies on the ecological impact of antibiotic therapy prescription for respiratory infections by taking nasopharyngeal specimens before and after treatment
  • Taking advantage of our expertise in this field (thousands of children), the logical result has been a surveillance of pneumococcal conjugated vaccine for this flora (surveillance of nasopharyngeal carriage of S. pneumoniae since 2001)
  • Some studies of RDTs for GAS performed have led to generalized RDTs for GAS in France. Indeed, these studies have contributed to RDT performance evaluation (sensitivity, specificity, predictive values) and allowed for checking their applicability to clinical practice
  • Following the same idea, ACTIV works on RDTs for flu and a CRP micromethod.

Our team ensures the process of projects from their implementation to the final report and national and international publication.

Les sociétés suivantes sont partenaires d'ACTIV
Association à but non lucratif
31, rue Le Corbusier - 94 000 Créteil
Tel : +33 (0)1 48 85 04 04